Innovative PBM Solutions: Elevating PRP and Cellular Therapies

Ex-vivo Photobiomodulation (PBM) of Platelets and Progenitor Cells combined with Exosomes and Plasma Proteins:

  • Most of the light administered topically is scattered with very little of the therapy reaching deep tissue, especially joint tissue.  

    Companies recommend a NIR 980nm frequency for orthopedic use because it can penetrate deeper into tissue. However,  980nm frequency is less likely to interact with a cell’s chromophore.

    Lowering the frequency to 640nm makes the light more likely to interact with a cell’s chromophore but that frequency of light is unable to penetrate deeper into tissue.  

  • Use a NIR 640nm & 810 frequency on the blood sample ex-vivo prior to making PRP to ensure efficient mitochondrial interaction with the light. 

    The surface area afforded by a clear bag is an ideal medium to perform this step to improve the mitochondrial function of the sample. The PRP that has benefitted from the photobiomodulation step is then injected deeper inside the body to provide maximum benefit to the patient.

    • Reduction in inflammation

    • Improved platelet function

    • Improved mitochondrial function

    • Better outcomes

  • “Using the patient as their own control, the difference at 5 months in hair growth between the side where the Platelet concentrate made from whole blood was pre-conditioned with (PBM) and the side using a standard Platelet concentrate was as follows:

    1. More new hairs

    2. Fewer malnourished hairs

    3. Significantly higher hair density

    4. No adverse events.”

    “PBM of the whole blood sample prior to making PRP enhanced the ability of CD34+ cells to secrete growth factors that had a long-lasting effect on hair growth.”

    “Transplanted adipose grafts preconditioned with PBM had better outcomes in a human model of hypertrophic scars.”

    “Low-level laser illumination may affect ADSCs growth processes and ADSC-assisted lipo-transfer for soft tissue deformity, scar treatment, wound healing, and other reconstructive surgery.”