Significant Untapped Potential in Regenerative Medicine

Platelets combined with Exosomes and Plasma Protein:

  • An increasing body of literature suggests that concentrating proteins and exosomes in addition to platelets will improve PRP results, perhaps DRAMATICALLY.  

  • There are over 1,000 different exosomes and proteins found in plasma that cannot be concentrated by a simple tabletop, low G-force, centrifugation process.   

  • Capturing the solid portion of blood plasma is likely to have significant therapeutic value. 

  • Blood plasma contains 91% to 92% water and 8% to 9% solids. 

  • The solid portion of plasma contains extracellular vesicles and proteins; fibrinogen, albumin, globulin, immunoglobulins, and electrolytes.

  • “This study demonstrates that fibrinogen is safe and a widely available extracellular matrix that can be used as a versatile scaffold for cells.”

    (Tatsufumi Mori, et al  Fibrinogen supports self-renewal of mesenchymal stem cells under serum-reduced condition through autophagy activation, Biochemical and Biophysical Research Communications, Volume 651, 2023, Pages 70-78)

    “In our opinion, fibrin-based matrices have emerged as a promising biological and multipurpose platform due to their high cellular-adhesion capacity."

    (Everts, P.A.; et al. Profound Properties of Protein-Rich, Platelet-Rich Plasma Matrices as Novel, Multi-Purpose Biological Platforms in Tissue Repair, Regeneration, and Wound Healing. Int. J. Mol. Sci. 2024, 25, 7914.)

Buffy bag.
Buffy Syringe.